IVD reagent ibikoresho Ikimenyetso cyumutima

Cardiac Troponin I (cTnI) ni ubwoko bwumuryango wa troponine ukunze gukoreshwa nkikimenyetso cyo kwangirika kwa myocardial.Cardiac troponin I yihariye ingirangingo z'umutima kandi igaragara muri serumu gusa iyo habaye imvune ya myocardial.Kuberako umutima wa troponine I ari ikintu cyerekana cyane kandi cyihariye cyerekana imitsi yumutima (myocardium) kwangirika, urugero rwa serumu rushobora gukoreshwa kugirango rufashe gutandukanya angina idahindagurika na infarction myocardial (umutima utera) kubantu bafite ububabare bwo mu gatuza cyangwa syndrome de coronary.

Cardiac isoform ya TnT ikoreshwa cyane nkikimenyetso cyimvune ya myocardial selile, nkuko cTnI imeze.cTnT ifite kinetics imwe irekura mumaraso kandi ikumva kimwe no gukomeretsa byoroheje myocardial nka cTnI.Mu maraso yabarwayi ba myocardial infarction (AMI), cTnT ikunze kuboneka muburyo bwubusa mugihe cTnI iboneka cyane hamwe na TnC.

Troponine C, izwi kandi nka TN-C cyangwa TnC, ni poroteyine iba mu ruganda rwa troponine kuri actin yoroheje ya filaments yimitsi ikaze (umutima, skelete yihuta, cyangwa skeletal buhoro) kandi ishinzwe guhuza calcium kugirango ikore kugabanuka kw'imitsi.Troponine C igizwe na gene ya TNNC1 mubantu kubwimitsi yumutima hamwe na skeletale itinda.

myoglobine ni poroteyine ya cytoplasmeque ihuza ogisijeni mu itsinda rya heme.Ifite itsinda rimwe gusa rya globuline, naho hemoglobine ifite bane.Nubwo itsinda ryayo rya heme risa nkiryo muri Hb, Mb ifitanye isano ya ogisijeni kuruta hemoglobine.Iri tandukaniro rifitanye isano ninshingano zaryo zitandukanye: mugihe hemoglobine itwara ogisijeni, imikorere ya myoglobine ni ukubika ogisijeni.

Digoxin ikoreshwa mu kuvura kunanirwa k'umutima, hamwe n'indi miti.Irakoreshwa kandi mu kuvura ubwoko bumwebumwe bwumutima udasanzwe (nka fibrillation idakira).Kuvura kunanirwa k'umutima birashobora kugufasha gukomeza ubushobozi bwawe bwo kugenda no gukora siporo kandi birashobora kunoza imbaraga z'umutima wawe.Kuvura umutima udasanzwe birashobora kandi kunoza ubushobozi bwawe bwo gukora siporo.Digoxin ni murwego rwimiti yitwa cardiac glycoside.Ikora ikora ku myunyu ngugu (sodium na potasiyumu) ​​imbere mu ngirangingo z'umutima.Ibi bigabanya imihangayiko kumutima kandi bikayifasha gukomeza umutima usanzwe, uhamye, kandi ukomeye.

CK-MB mu ndwara ikaze ya myocardial (AMI), na CK-BB mu kwangiza ubwonko no kubyimba nabi kwa gastro-amara.CK-MB ipimwa haba mubikorwa bya enzyme cyangwa kwibumbira hamwe kandi bipimwa nkikimenyetso atari mugupima AMI gusa ahubwo no mubikekwa AMI na angina idahindagurika.

Ubwoko bwumutima-Ibinure-Acide-Binding-Protein (hFABP) ni poroteyine, igira uruhare mu gutwara myocardial intracellular (Bruins Slot et al., 2010; Reiter et al., 2013).Nyuma ya myocardial necrosis hFABP irekurwa byihuse mumaraso bityo hakorwa iperereza nka biomarker ya AMI.Ariko, kubera sensibilité nkeya kandi yihariye hFABP ntabwo byagaragaye ko ari ingirakamaro, ugereranije nibikorwa byo gusuzuma hs-Tn (Bruins Slot et al., 2010; Reiter et al., 2013).

Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)

Lipide ni ibinure mumaraso yawe.Lipoproteine ​​ni ihuriro ryamavuta na proteyine bitwara amavuta mumaraso yawe.Niba ufite Lp-PLA2 mumaraso yawe, urashobora kugira ibinure byamavuta mumitsi yawe ishobora guturika no gutera indwara z'umutima cyangwa inkorora.

D-dimer (cyangwa D dimer) nigicuruzwa cya fibrin (cyangwa FDP), agace gato ka poroteyine kiboneka mumaraso nyuma yo gutembera kwamaraso kwa fibrinolysis.Yiswe cyane kuko irimo ibice bibiri D bya poroteyine ya fibrin ihujwe no guhuza.