Ku ya 9 Ugushyingo 2021, impinduka yacoronavirus nshyaB.1.1.529 yatahuwe bwa mbere uhereye ku cyitegererezo cy’urubanza rwo muri Afurika yepfo.Mugihe kitarenze ibyumweru 2, ihinduka ryimiterere ya mutant ryiganje muri mutant yepfo y’indwara nshya zanduye muri Afurika yepfo, kandi iterambere ryayo ryihuse ryashimishije isi yose.Ku ya 26 Ugushyingo, iyi miterere ya mutant yasobanuwe na OMS ko ari “impinduka ya gatanu” (VOC), yitwa Omicron (Omicron) mutant.Kugeza ubu, ubwoko bwa Omicrom butandukanye bwakwirakwiriye mu bihugu 19 cyangwa uturere 19 ku isi, kandi bushobora guteza ibibazo bishya mu gukumira no kurwanya icyorezo ku isi.
OMS yavuze kandi ko Omicron ifite umubare munini w'imihindagurikire, bimwe muri byo bikaba biteye impungenge.OMS yavuze kandi ko imiterere ya “Omicron” ihinduka vuba kurusha iyindi miterere ya mutant yateje ubwiyongere bw'indwara mu bihe byashize, byerekana ko iyi miterere iheruka ishobora kugira inyungu zo gukura.Kurinda byimazeyo ikwirakwizwa rya mutant ya coronavirus nshya Omicron yabaye intego nshya yo gukumira icyorezo ku isi
Ikarita yo gukwirakwiza ihinduka rya Omicron(1)na Delta(2), Ububiko bwa kaminuza ya Stanford Coronavirus nububiko bwibiyobyabwenge
Usibye kugira ihinduka ryinshi muri poroteyine ya spike, imiterere ya Omicron ihinduka kandi ifite ibibanza byinshi byahinduwe muri poroteyine N.Kubera ko intego nyamukuru ya coronavirus antigen detection reagent ari proteine ya N, ihinduka rya poroteyine N rishobora kugira ingaruka kuri antigen nshya ya coronavirus.Ubusobanuro bwibikoresho byikizamini bifite ingaruka.
Imbonerahamwe 1. Kugereranya N protein ihindagurika rya mutant zitandukanye
| |
Kurwanya virusi
| Ubwihindurize bwa poroteyine |
Alpha (B.1.1.7) | R203K;G204R; (> 50%) S194L (5-50%) D3H; D63G; T205I; M234I (1-5%) |
Beta (B.1.351) | T205I (> 50%) P13S; T3621 (5-50%) Q9H; Q28R; A35T; E38V; Q418H (1-5%) |
Gamma (p.1) | P80R; S202C; R203K; G204R (> 50%) A211S; D402Y; S4131 (1-5%) |
Delta (B.1.617.2) | D63G; R203M; G215C; D377Y (> 50%) Q9L (> 5-50%) G18V; R385K (1-5%)
|
Omicron (B.1.1.529) | P13L; R203K; G204R E31 / R32 / S33 Del |
Ugereranije na poroteyine ya Alpha-N, poroteyine ya Omicron-N ifite itandukaniro ryimyanya 10 ya aside amine.Kugirango dukore iperereza ku mikorere ya poroteyine ya Omicron-N na covid-19 antibody mbisi ya gene ya Keygen, twateguye proteine ya recombinant Omicron-N ku nshuro yambere, kandi dukora igenzura ryakozwe na Keygen Gene hamwe nabakiriya benshi.Ibisubizo byerekana ko gufungura gene ibintu bishya bya antibody ibikoresho bifite ibisubizo bimwe byo gutahura proteine ya Oombron-N, proteine ya Alpha-N na proteine ya Delta-N.Gufungura kureba gene ibikoresho bishya bya antibody birashobora kwemeza neza niba virusi nshya ya antigen kit yo kumenya neza Omicron..
Imbonerahamwe 2 Ibisubizo byo kumenya Omicron recombinant N proteine na antibody ya neocorona | ||||||
Antibody Byombi | Alpha-Nprotein | Omicron-Nprotein | ||||
4.0ng / ml | 2.0ng / ml | 1.0ng / ml | 4.0ng / ml | 2.0ng / ml | 1.0ng / ml | |
Gahunda 1 | G5 | G4 | G2 | G5 | G4 | G2 |
Gahunda 2 | G5 | G4 | G2 | G5 | G4 | G2 |
Ikarita ya zahabu yerekana ikarita itandukanye
Kuburugero nyamuneka hamagara sales03@sc-sshy.com
Igihe cyo kohereza: Ukuboza-14-2021