Iterambere ry'utugari rifite ibisabwa cyane ku bidukikije, ubushyuhe, agaciro ka PH, n'ibindi, kandi ubwiza bw'ibikoreshwa mu ngirabuzimafatizo bikoreshwa mu muco w'akagari nabyo bizagira ingaruka ku mikurire y'utugari.Urugandani ibisanzwe bikoreshwa mugukurikiza umuco w'akagari, kandi ubwiza bwacyo bugira ingaruka kubintu bine.

1. murwego rwubuvuzi nibicuruzwa biva mumashanyarazi ikoreshwa mubuzima bwa biomedical test yipimishije cyane, bihuye nibisobanuro byubushakashatsi bwa laboratoire butari ivuriro.

2, ibidukikije bibyara umusaruro: selile zumva cyane ibidukikije bikura, birasabwa rero ko ibikoreshwa bitagomba kuba birimo endotoxine nibindi bintu byangiza ingirabuzimafatizo, ibyo bikaba bitanga ibisabwa cyane mubidukikije.Ibikoreshwa bigomba gukorerwa mu cyumba cyabigenewe ibihumbi icumi byabigenewe, kandi bigomba gukorerwa igenzura rikomeye (gutahura plankton, bacteri zo mu mitsi hamwe nuduce twahagaritswe).Imicungire myiza igomba gukorwa hakurikijwe amahugurwa ya GMP kugirango habeho umutekano w’ibidukikije.

3, kugenzura imikorere yumusaruro: ibi bivuga ibicuruzwa mubikorwa byumusaruro wa buri murongo harimo, nkibipimo byo gutera inshinge, ubushyuhe bwinshinge, nibindi, bizagira ingaruka kumiterere yibicuruzwa byarangiye.

4, ubugenzuzi bufite ireme: kugenzura ubuziranenge ni inzira yingenzi nyuma yo kurangiza umusaruro w’uruganda rw’utugari, ibintu bizageragezwa birimo kashe, umutekano w’ibinyabuzima, umutekano w’umubiri n’imiti, kugenzura ibicuruzwa byemewe, hydrophilique y’ubutaka, nibindi, binyuze muri ibyo bizamini kugirango umenye niba ibicuruzwa byujuje ubuziranenge.

Ibintu bigira ingaruka kumiterere yinganda zinganda ahanini zirimo ibintu bine byavuzwe haruguru.Gusa mugucunga ibyo bintu neza dushobora kubyara ibicuruzwa byujuje ubuziranenge bityo tugatanga ibidukikije byiza byo gukura kwakagari.